Focus 1: Joint Tissue Healing
Until now, we have principally addressed articular cartilage healing and will continue to do so, but we want to enlarge the focus to include other tissues.
 Enhanced Cartilage Repair by Gene-Mediated Combination Insulin-Like Growth Factor-1/Interleukin-1 Receptor Antagonist Therapy--An In-Vitro Study
Focus 2: Early Diagnosis of Bone and Joint Disease
This includes the development of novel imaging techniques (present and future), body fluid markers and also molecular monitoring. The uses of these early diagnostic techniques include:
a. evaluation of the pathogenesis of bone and joint disease
b. early detection of disease processes
c. monitoring of therapy, with the long term goal of preventing severe arthritis or failure
Using Blood Samples to Monitor the Effects of Exercise on Musculoskeletal Development in Foals
Evaluation of Bone Density in the Equine Third Metacarpal Condyle
Indicators of Collagen Degradation in a Canine Model of Osteoarthritis
Evaluation of Nuclear Scintigraphy for Early Diagnosis of Non-union and Infected Non-union
The Effect of Exercise on Synovial Fluid and Serum Markers of Musculoskeletal Diseases in Horses with and without Osteochondral Fragmentation
Evaluation of Methods for RNA Isolation and cDNA Synthesis Using Small Articular Cartilage Samples
Evaluation of Serum Bone Markers for Early Diagnosis of Non-union and Infected Non-union
Testing the Tekscan System as a Tool for Objectively Measuring Lameness in the Horse
Use of Serum Biomarkers to Evaluate OA Treatment Using Gene Transfer
An Historical Cohort Study of Yearling Radiographic Changes and Racing Performance in Thoroughbreds
Focus 3: Improvement in the Understanding of the Pathogenesis of Exercise-Induced Traumatic Disease
These investigations use both molecular tools such as reverse transcriptase PCR evaluation of tissues in various stages of disease, as well as biomechanical studies.
A New Method of Detecting Cartilage Damage in Horses
Relationship between Equine Cartilage Mechanical Properties and Biochemical Composition
Blood Tests to Identify Alterations in Skeletal Tissue Turnover in Developmental Orthopaedic Disease in Horses
Focus 4: Continued Development of Novel Therapies for Traumatic Synovitis, Capsulitis and Osteoarthritis in the Horse
These include evaluation of metalloproteinase inhibitors and the use of gene therapy techniques.
Arthroscopic Technique for Transection of the Canine Cranial Cruciate Ligament
Gross and Microscopic Pathologic Changes in Cranial Cruciate Ligament Deficient Dogs: Effectiveness of an Enzyme Inhibitor of Cartilage Breakdown
Evaluation of the Dynamix Shoe for Alleviating Hoof Stress
Enhancement of Fracture Healing Using Adenoviral Transfer of the BMP-2 Gene in an Infected Non-union Model
Effectiveness of an Enzyme Inhibitor of Cartilage Breakdown by Force Plate Analysis in Cranial Cruciate Ligament Deficient Dogs
Evaluation of Pentosan Polysulfate
Current Research
Charismatic Project
Global Equine Research Alliance Study
Evaluation of Interleukin-1 Receptor Antagonist Delivered Using an Adeno Associated Viral Vector for Treatment of Experimentally Created Osteoarthritis in the Horse
Other Current Research Projects
Mission
Our mission is investigation in the pathogenesis, diagnosis, treatment and prevention of musculoskeletal disease for the betterment of animals and humans.
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